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An Easy Access to Oxime Ethers by Pd‐Catalyzed C—O Cross‐Coupling of Activated Aryl Bromides with Ketoximes and Chalcone Oximes
Author(s) -
Rangarajan T. M.,
Singh Raj Pal,
Singh R. P.,
Singh Manjula
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900540
Subject(s) - chemistry , chalcone , oxime , aryl , catalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , alkyl
Summary of main observation and conclusion An efficient Pd‐catalyzed method for C—O cross‐coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo‐chalcones has been developed. All oxime ethers were obtained in good to excellent yields by [(π‐allyl)PdCl] 2 / t BuXPhos ( L7 ) catalyst system. TrixiePhos ( L11 ) was also found to be effective for the oxime coupling. This method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo‐chalcones, which has not been previously explored.