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Visible Light‐Induced Copper‐Catalyzed C—H Arylation of Benzoxazoles †
Author(s) -
Ma Xiaodong,
Zhang Guozhu
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900527
Subject(s) - chemistry , benzothiazole , aryl , copper , halide , thiophene , alkoxide , lithium (medication) , catalysis , visible spectrum , coupling (piping) , combinatorial chemistry , medicinal chemistry , photochemistry , organic chemistry , alkyl , optoelectronics , medicine , physics , endocrinology , mechanical engineering , engineering
Summary of main observation and conclusion A general method for visible light‐induced copper‐catalyzed arylation of sp 2 C—H bonds of azoles has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide as base. A variety of azoles including benzooxazole and benzothiazole can be arylated. Furthermore, electron‐poor heterocycles such as thiophene possessing one electron‐withdrawing group can also be arylated.