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Highly Stereoselective Direct Construction of Diaryl‐Substituted Cyclobutanes †
Author(s) -
Song XiangYang,
Zhao LiuPeng,
Wang Lijia,
Tang Yong
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900456
Subject(s) - cyclobutanes , chemistry , stereoselectivity , yield (engineering) , enantioselective synthesis , stereospecificity , catalysis , copper , combinatorial chemistry , stereochemistry , organic chemistry , cycloaddition , materials science , metallurgy
Summary of main observation and conclusion A copper catalyzed stereoselective [2+2] cyclization has been developed, providing a concise protocol to the direct construction of diaryl‐substituted cyclobutanes in up to 99% yield with up to >95/5 dr. Meanwhile, the enantioselective version of this reaction has also been achieved, leading to a series of optically active diaryl‐substituted cyclobutanes with up to 94% ee.
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