Premium
Palladium‐Catalyzed Coupling of Propargylic Alcohols with Boronic Acids under Ambient Conditions
Author(s) -
Qin Anni,
Qian Hui,
Chen Qin,
Ma Shengming
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900442
Subject(s) - chemistry , palladium , catalysis , tetra , boronic acid , combinatorial chemistry , functional group , coupling (piping) , reaction conditions , organic chemistry , medicinal chemistry , polymer , mechanical engineering , engineering
Summary of main observation and conclusion A highly efficient palladium‐catalyzed direct coupling of propargylic alcohols with organoboronic acids to synthesize tri‐ and tetra‐substituted allenes has been developed under mild reaction conditions. Many useful functional groups are tolerated in this process with high to excellent yields. Preliminary biological studies showed that several tri‐ and tetra‐substituted allenes exhibited potent anti‐diabetic activities.