Synthesis of CF 2 H‐Containing Oxime Ethers Derivatives from ClCF 2 H,  tert ‐Butyl Nitrile and Indoles | Zendy

Ma Xingxing | Zendy; Huang Hua | Zendy; Su Jianke | Zendy; Song Zhiyi | Zendy; Nakano Tamaki | Zendy; Song Qiuling | Zendy

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Synthesis of CF 2 H‐Containing Oxime Ethers Derivatives from ClCF 2 H, tert ‐Butyl Nitrile and Indoles

Author(s) -

Ma Xingxing,

Huang Hua,

Su Jianke,

Song Zhiyi,

Nakano Tamaki,

Song Qiuling

Publication year - 2020

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201900401

Subject(s) - chemistry , nitrile , oxime , combinatorial chemistry , medicinal chemistry , indole test , organic chemistry

Summary of main observation and conclusion A new and intriguing methodology to access various O ‐difluoromethylation oxime compounds from ClCF 2 H, TBN and indoles is developed under mild reaction conditions. This strategy can suppress N ‐difluoromethylation of indoles successfully, in which there are two different active species (:CF 2 and ·NO) while indoles are unprotected, featuring simple operation and radical involvement.

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