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Synthesis of CF 2 H‐Containing Oxime Ethers Derivatives from ClCF 2 H, tert ‐Butyl Nitrile and Indoles
Author(s) -
Ma Xingxing,
Huang Hua,
Su Jianke,
Song Zhiyi,
Nakano Tamaki,
Song Qiuling
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900401
Subject(s) - chemistry , nitrile , oxime , combinatorial chemistry , medicinal chemistry , indole test , organic chemistry
Summary of main observation and conclusion A new and intriguing methodology to access various O ‐difluoromethylation oxime compounds from ClCF 2 H, TBN and indoles is developed under mild reaction conditions. This strategy can suppress N ‐difluoromethylation of indoles successfully, in which there are two different active species (:CF 2 and ·NO) while indoles are unprotected, featuring simple operation and radical involvement.