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Ir/Phase‐Transfer‐Catalysis Cooperatively Catalyzed Asymmetric Cascade Allylation/2‐aza‐Cope Rearrangement: An Efficient Route to Homoallylic Amines from Aldimine Esters †
Author(s) -
Wei Liang,
Xiao Lu,
Wang ZuoFei,
Tao HaiYan,
Wang ChunJiang
Publication year - 2020
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900391
Subject(s) - chemistry , aldimine , catalysis , ammonium bromide , bimetallic strip , cascade , combinatorial chemistry , bromide , phase (matter) , organic chemistry , pulmonary surfactant , biochemistry , chromatography
Summary of main observation and conclusion Herein, we developed an Ir/phase‐transfer‐catalysis cooperatively catalyzed asymmetric cascade allylation/2‐aza‐Cope rearrangement of aldimine esters to prepare synthetically important homoallylic amines in good yields with excellent enantioselectivities. Compared with the bimetallic catalytic system to realize this transformation, the current cooperative Ir/tetrabutyl ammonium bromide catalytic system provides an alternative but more practical approach, which not only simplify the manipulation process but also increase the cost efficiency.