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Copper‐Catalyzed Benzylic C—H Functionalization, Oxidation and Cyclization of Methylarenes: Direct Access to 2‐Arylbenzothiazoles
Author(s) -
Yu Wentao,
Wu Wanqing,
Jiang Huanfeng
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900340
Subject(s) - chemistry , surface modification , catalysis , copper , sulfide , potassium , medicinal chemistry , combinatorial chemistry , organic chemistry
Summary of main observation conclusion The direct C—H functionalization of methylarenes is of great significance. Herein, a copper‐catalyzed oxidative C—N/C—S bond formation through benzylic C(sp 3 )—H functionalization, oxidation and cyclization of methylarenes is reported. Various 2‐arylbenzothiazoles have been synthesized in moderate to excellent yields with readily available o ‐iodoaniline, potassium sulfide, and methylarenes as raw materials.