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General and Phosphine‐Free Cobalt‐Catalyzed Hydrogenation of Esters to Alcohols
Author(s) -
Shao Zhihui,
Zhong Rui,
Ferraccioli Raffaella,
Li Yibiao,
Liu Qiang
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900292
Subject(s) - chemistry , catalysis , phosphine , organic chemistry , cobalt , turnover number , catalytic hydrogenation , noble metal , combinatorial chemistry
Summary of main observation and conclusion Catalytic hydrogenation of esters is essential for the sustainable production of alcohols in organic synthesis and chemical industry. Herein, we describe the first non‐noble metal catalytic system that enables an efficient hydrogenation of non‐activated esters to alcohols in the absence of phosphine ligands (with a maximum turnover number of 2391). The general applicability of this protocol was demonstrated by the high‐yielding hydrogenation of 39 ester substrates including aromatic/aliphatic esters, lactones, polyesters and various pharmaceutical molecules.