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Bifunctional Ion Pair Catalysts from Chiral α‐Amino Acids
Author(s) -
Wang Hongyu,
Zheng Changwu,
Zhao Gang
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900276
Subject(s) - chemistry , bifunctional , catalysis , enantioselective synthesis , hydrogen bond , phosphonium , ammonium , ion , combinatorial chemistry , amino acid , molecule , computational chemistry , organic chemistry , biochemistry
Asymmetric ion pair catalysis presents a powerful strategy for the construction of chiral molecules. However, the ion‐pair interactions are weakly directional and result in difficultly controlling the conformational constraint for high stereo‐ inductions. Based on the hydrogen bonding interactions, we have successfully designed and synthesized a new family of bifunctional ion pair catalysts derived from chiral amino acids via simple operations. With these chiral ammonium salts and phosphonium salts in hand, the enantioselective construction of C—C and C—X bonds was realized in our lab.