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Copper‐Catalyzed Oxidative Dearomatization of 2‐Naphthols via Etherification
Author(s) -
Yi JiCheng,
Wu ZhiJie,
You ShuLi
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900242
Subject(s) - chemistry , catalysis , intermolecular force , copper , oxidative phosphorylation , combinatorial chemistry , organic chemistry , reaction conditions , molecule , biochemistry
Summary of main observation and conclusion Copper‐catalyzed intermolecular oxidative‐etherification type dearomatization reaction of 2‐naphthols was developed. With air as the terminal oxidant, the reaction proceeded in excellent yields under mild conditions. In addition, the reaction between two different naphthol substrates occurred smoothly. A series of multifunctionalized β‐naphthalenones, important scaffold existed widely in natural products and biologically active molecules, were synthesized efficiently.