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Rational Fabrication and Biomedical Application of Biomolecule‐Conjugated AIEgens through Click Reaction
Author(s) -
Yuan Qiming,
Cheng Yong,
Lou Xiaoding,
Xia Fan
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900211
Subject(s) - biomolecule , nanotechnology , conjugated system , photobleaching , chemistry , aggregation induced emission , biomedicine , rational design , cancer treatment , fluorescence , cancer , materials science , bioinformatics , polymer , organic chemistry , biology , physics , genetics , quantum mechanics
Recently, the issue of cancer has attracted extensive attention. Early diagnosis and timely therapy are important for cancer treatment. And lots of advanced fluorescent probes have been applied to cancer theranostics. However, the further development of these probes is limited by the disadvantages of poor targeting, weak sensitivity and photobleaching. Fortunately, the emergence of biomolecule‐conjugated fluorescent probes with aggregation‐ induced emission properties has taken innovative impetus to the cancer theranostics. This review summarizes the rational fabrication and biomedical applications of biomolecule‐conjugated AIE luminogens (AIEgens) based on “click reaction” over the past decade. In the meantime, the challenges of biomolecule‐conjugated AIEgens in the field of biomedicine are also discussed.