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Chiral Frustrated Lewis Pairs Catalyzed Highly Enantioselective Hydrosilylations of Ketones
Author(s) -
Liu Xiaoqin,
Wang Qiaotian,
Han Caifang,
Feng Xiangqing,
Du Haifeng
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900121
Subject(s) - enantioselective synthesis , chemistry , borane , frustrated lewis pair , hydrosilylation , catalysis , optically active , diene , lewis acids and bases , organic chemistry , natural rubber
Summary of main observation and conclusion A highly enantioselective Piers‐type hydrosilylation of simple ketones was successfully realized using a chiral frustrated Lewis pair of tri‐ tert ‐butylphosphine and chiral diene‐derived borane as catalyst. A wide range of optically active secondary alcohols were furnished in 80%—99% yields with 81%—97% ee's under mild reaction conditions.