Supramolecular Vesicles Based on Water‐Soluble 2,6‐Helic[6]arene: High Affinity Binding, Stimuli Responsiveness and Delivery of Doxorubicin to Cancer Cells | Zendy

Yang Xuan | Zendy; Mao Weipeng | Zendy; Liu Yamin | Zendy; Li Libai | Zendy; Ma Da | Zendy

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Supramolecular Vesicles Based on Water‐Soluble 2,6‐Helic[6]arene: High Affinity Binding, Stimuli Responsiveness and Delivery of Doxorubicin to Cancer Cells

Author(s) -

Yang Xuan,

Mao Weipeng,

Liu Yamin,

Li Libai,

Ma Da

Publication year - 2019

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201900093

Subject(s) - chemistry , supramolecular chemistry , hela , vesicle , doxorubicin , in vitro , drug delivery , biophysics , combinatorial chemistry , biochemistry , membrane , organic chemistry , molecule , chemotherapy , medicine , biology , surgery

Summary of main observation and conclusion Water‐soluble 2,6‐helic[6]arene was used to construct supramolecular vesicles via host‐guest interaction. Water‐soluble 2,6‐helic[6]arene was discovered to be high affinity host for suitable biomarkers. Supramolecular vesicles were responsive to multiple stimuli types, including temperature, pH, Ca 2+ , CO 2 bubbling and biomarker displacement. Supramolecular vesicles were used to load and deliver anti‐ tumor drug doxorubicin to HeLa cells in vitro .

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