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Supramolecular Vesicles Based on Water‐Soluble 2,6‐Helic[6]arene: High Affinity Binding, Stimuli Responsiveness and Delivery of Doxorubicin to Cancer Cells
Author(s) -
Yang Xuan,
Mao Weipeng,
Liu Yamin,
Li Libai,
Ma Da
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900093
Subject(s) - chemistry , supramolecular chemistry , hela , vesicle , doxorubicin , in vitro , drug delivery , biophysics , combinatorial chemistry , biochemistry , membrane , organic chemistry , molecule , chemotherapy , medicine , biology , surgery
Summary of main observation and conclusion Water‐soluble 2,6‐helic[6]arene was used to construct supramolecular vesicles via host‐guest interaction. Water‐soluble 2,6‐helic[6]arene was discovered to be high affinity host for suitable biomarkers. Supramolecular vesicles were responsive to multiple stimuli types, including temperature, pH, Ca 2+ , CO 2 bubbling and biomarker displacement. Supramolecular vesicles were used to load and deliver anti‐ tumor drug doxorubicin to HeLa cells in vitro .