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The [4 + 2] Cycloaddition of 2‐Pyrone in Total Synthesis
Author(s) -
Cai Quan
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201900048
Subject(s) - chemistry , cycloaddition , pyrone , total synthesis , diene , organic chemistry , combinatorial chemistry , catalysis , natural rubber
Diels‐Alder reaction is one of the most important reactions in organic synthesis and has witnessed great achievements in total syntheses of complex natural products. In this review, we will focus on the [4 + 2] cycloaddition that utilizes 2‐pyrone as the diene component. Major advances of its applications in the total syntheses of natural products in the past fifty years will be discussed here.