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Back Cover: Internally Reuse Waste: Catalytic Asymmetric One‐Pot Strecker Reaction of Fluoroalkyl Ketones, Anilines and TMSCN by Sequential Catalysis (Chin. J. Chem. 4/2018)
Author(s) -
Liu YunLin,
Yin XiaoPing,
Zhou Jian
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201880045
Subject(s) - strecker amino acid synthesis , chemistry , catalysis , bifunctional catalyst , bifunctional , enantioselective synthesis , reactivity (psychology) , organic chemistry , cyanohydrin , amine gas treating , aryl , medicine , alkyl , alternative medicine , pathology
A highly enantioselective one‐pot Strecker reaction of α‐fluoroalkyl α‐aryl ketones, anilines, and TMSCN is disclosed, which simultane‐ously reuses water byproduct and catalyst from the ketimine formation step as a promoter and an additive to improve the reactivity and enantioselectivity of the subsequent Strecker reaction, respectively. The picture shows that the chiral bifunctional tertiary amine mediated asymmetric Strecker reaction is irrigated by the water generated in the p‐TsOH catalyzed ketimine formation, and fertilized by the remaining acid catalyst. More details are discussed in the article by Zhou et al. on page 321–328.