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Back Cover: Dual Stereocontrol for Enantioselective Hydrogenation of Dihydroisoquinolines Induced by Tuning the Amount of N ‐Bromosuccinimide (Chin. J. Chem. 2/2018)
Author(s) -
Ji Yue,
Wang Jie,
Chen Muwang,
Shi Lei,
Zhou Yonggui
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201880026
Subject(s) - chemistry , enantioselective synthesis , n bromosuccinimide , iridium , enantiomer , chin , binap , dual (grammatical number) , cover (algebra) , asymmetric hydrogenation , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , halogenation , medicine , art , mechanical engineering , literature , engineering , anatomy
The back cover picture shows an efficient dual enantioselective synthesis of 1‐substituted 1,2,3,4‐tetrahydroisoquinoline, which was realized through iridium‐catalyzed hydrogenation of 1‐substituted 3,4‐dihydroisoquinolines. Only tuning the amount of N‐bromosuccinimide, this reaction promoted by (R)‐BINAP is able to furnish both enantiomers of products up to 89% ee ( S ) and 98% ee ( R ), respectively. Dual activation role of N ‐bromosuccinimide is proposed to be responsible for the reversal of enantioselectivity under two hydrogenation conditions. More details are discussed in the article by Zhou et al. on page 139–142.