Premium
Chemical Intervention on Staphylococcus aureus Virulence
Author(s) -
Zhou LinLin,
Yang CaiGuang
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800470
Subject(s) - staphylococcus aureus , virulence , antibiotics , pathogenicity , microbiology and biotechnology , antibiotic resistance , pseudomonas aeruginosa , virulence factor , chemistry , bacteria , biology , gene , genetics , biochemistry
Resistance to conventional antibiotics has raised worldwide attention. Notably, Methicillin‐resistant Staphylococcus aureus (MRSA) has become one of the most life‐threatening health concerns. Although effective against bacterial infections, conventional antibiotics have also showed a series of side effects such as gut microbiota imbalance. An alternative is in urgent need in order to combat bacterial infections. Antivirulence represents a new approach to circumvent these shortcomings, which focuses on disarming the “weapons” for pathogenicity without much selective pressure on bacterial survival. In this review, we place emphasis on the chemical modulation of biosynthesis, assembly, function and the regulation of some major virulence factors in S. aureus , which we hope will help the development of antivirulence modulators.