Premium
NaBAr F 4 ‐Catalyzed Oxidative Cyclization of 1,5‐ and 1,6‐Diynes: Efficient and Divergent Synthesis of Functionalized γ‐ and δ‐Lactams
Author(s) -
Zhu BoHan,
Wang CaiMing,
Su HongYu,
Ye LongWu
Publication year - 2019
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800437
Subject(s) - chemistry , catalysis , oxidative phosphorylation , combinatorial chemistry , oxidative addition , rhodium , lewis acids and bases , substrate (aquarium) , transition metal , scope (computer science) , organic chemistry , biochemistry , oceanography , computer science , programming language , geology
Summary of main observation and conclusion An efficient NaBAr F 4 ‐catalyzed oxidative cyclization of readily available 1,5‐ and 1,6‐diynes has been developed. Importantly, this transition metal‐free oxidative catalysis proceeds via a presumable Lewis acid‐catalyzed S N 2’ pathway, which is distinct from the relevant oxidative rhodium and gold catalysis. This method leads to the facile and practical construction of a diverse range of synthetically useful γ‐ and δ‐lactams in mostly good to excellent yields with broad substrate scope.