Premium
Visible‐Light‐Induced Radical Cascade Cyclization: Synthesis of (20 S )‐Camptothecin, SN‐38 and Irinotecan
Author(s) -
Yuan Yao,
Dong Wuheng,
Gao Xiaoshuang,
Xie Xiaomin,
Curran Dennis P.,
Zhang Zhaoguo
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800358
Subject(s) - chemistry , camptothecin , propargyl , irinotecan , cascade , reagent , synthon , radical , combinatorial chemistry , catalysis , stereochemistry , organic chemistry , chromatography , medicine , colorectal cancer , cancer
(20 S )‐Camptothecin, irinotecan and SN‐38 were successfully synthesized by a photocatalyzed radical cascade cyclization from an N ‐propargyl iodopyridinone and an arylisonitrile under visible light with a ruthenium catalyst. This synthetic method provided a useful entry into composing camptothecin family of antitumor agents in good yields under mild reaction conditions without the use of heavy metal reagents.