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Rhodium(III)‐Catalyzed C—H Vinylation of Arenes: Access to Functionalized Styrenes
Author(s) -
Zhou Jun,
Li Xin,
Liao Gang,
Shi BingFeng
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800354
Subject(s) - chemistry , rhodium , catalysis , vinyltriethoxysilane , aryl , combinatorial chemistry , organic chemistry , reaction conditions , silane , alkyl
An effective method has been developed for Rh(III)‐catalyzed direct vinylation of arenes to give functionalized styrenes, using vinyltriethoxysilane as a convenient and inexpensive vinyl source. A wide variety of substrates, including 1‐aryl‐2‐pyrrolidinones, anilines, benzamides and ketones, were compatible with this reaction. Moreover, this method can be applied to the two‐step synthesis of functionalized indoles. Mechanistic investigation reveals that the reaction probably proceeds through an oxidative Heck/desilylation pathway.