Premium
Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross‐Coupling of Aryl Halides with Hydrazine Hydrate in Water
Author(s) -
Kumar Siripuram Vijay,
Ma Dawei
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800326
Subject(s) - chemistry , hydrazine (antidepressant) , aryl , hydrate , halide , bromide , catalysis , medicinal chemistry , ligand (biochemistry) , organic chemistry , biochemistry , alkyl , receptor , chromatography
The N,N ’‐bis(2,6‐dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu‐catalyzed cross‐coupling of aryl halides with hydrazine hydrate, leading to the formation of a variety of aryl hydrazines at 80 o C in water under the assistance of K 3 PO 4 and 4 mol% cetyltrimethylammonium bromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases.