Direct Synthesis of Structurally Divergent Indole Alkaloids from Simple Chemicals | Zendy

Shen Tao | Zendy; Zhu Bencong | Zendy; Lin Fengguirong | Zendy; Pan Jun | Zendy; Wei Jialiang | Zendy; Luo Xiao | Zendy; Liu Jianzhong | Zendy; Jiao Ning | Zendy

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Direct Synthesis of Structurally Divergent Indole Alkaloids from Simple Chemicals

Author(s) -

Shen Tao,

Zhu Bencong,

Lin Fengguirong,

Pan Jun,

Wei Jialiang,

Luo Xiao,

Liu Jianzhong,

Jiao Ning

Publication year - 2018

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201800258

Subject(s) - chemistry , indole test , tryptamine , tryptamines , combinatorial chemistry , cycloaddition , indole alkaloid , stereochemistry , organic chemistry , catalysis , biochemistry

A direct and structurally divergent synthesis of indole alkaloids from very simple 2‐vinylanilines, alkynes and TBN via a novel substrate fragmentation/cycloaddition strategy has been developed, which provides an efficient noble‐metal‐free approach to access a library of highly valuable indole derivatives of tryptamines and tryptamine‐related oximes, lactams, and lactones, as well as β‐carbolines, spiroindolines, and hexa‐hydropyrrolo[2,3‐ b ]indoles.

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