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Making Spiroketal‐based Diphosphine (SKP) Ligands via a Catalytic Asymmetric Approach
Author(s) -
Wang Xiaoming,
Ding Kuiling
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800247
Subject(s) - chemistry , enantiopure drug , catalysis , enantioselective synthesis , ligand (biochemistry) , combinatorial chemistry , stereochemistry , organic chemistry , receptor , biochemistry
The spiro concept for chiral ligand design represents an important contribution to the area of asymmetric catalysis. Due to the considerable difficulties in the construction of enantiopure all‐carbon spiro backbones, the development of catalytic asymmetric synthesis of chiral spiro structures via short steps is highly valuable. Herein we present our studies on the catalytic asymmetric synthesis of aromatic spiroketals and the corresponding diphosphine (SKP) ligands.