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Advances in DNA Origami Nanopores: Fabrication, Characterization and Applications
Author(s) -
Ren YongAn,
Gao Han,
Ouyang Xiangyuan
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800173
Subject(s) - nanopore , nanotechnology , characterization (materials science) , bottleneck , chemistry , nanopore sequencing , fabrication , dna origami , solid state , dna , computer science , nanostructure , materials science , dna sequencing , medicine , biochemistry , alternative medicine , pathology , embedded system
In recent years, bio‐nanopore and solid‐state nanopore have been greatly improved for molecule bio‐sensing. Whereas, the development of this scientific field seems to have encountered a bottleneck due to their respective limitations. The small pore size of the former impedes the detection of large single molecule, and the latter is difficult to achieve similar accuracy and functional control. DNA origami plays a novel role to bring more opportunities for the development of nanopore technology since it is relatively easy to synthesize and modify. This review mainly focuses on introducing the DNA origami nanopore fabrication methods, characterization and application. Meanwhile, the challenges in the present DNA origami nanopore research are also discussed.