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Direct C—H Bond Activation of Benzoxazole and Benzothiazole with Aryl Bromides Catalyzed by Palladium(II)‐ N‐ heterocyclic Carbene Complexes
Author(s) -
Kaloğlu Murat,
Kaloğlur Nazan,
Özdemir İsmail
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800166
Subject(s) - benzothiazole , chemistry , benzoxazole , carbene , palladium , aryl , catalysis , medicinal chemistry , reagent , combinatorial chemistry , organic chemistry , alkyl
Herein, we report that a series of novel palladium(II)‐NHC complexes (NHC= N ‐heterocyclic carbene) were synthesized. The structures of all novel complexes were characterized by 1 H NMR, 13 C NMR, FT‐IR spectroscopy and elemental analysis techniques. These palladium(II)‐NHC complexes were tested as efficient catalysts in the direct C—H bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 °C for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2‐arylbenzoxazoles and 2‐arylbenzothiazoles in acceptable to high yields.