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Metal Free Mono‐ and 2,3‐Bis‐sulfenylation of Indoles in Water with Sodium Sulfinates as a Sulfur Source
Author(s) -
Liu Changqing,
Fan Jian,
Wu Manyi,
Chen Jiahui,
Zhao Yiming,
Xie Meihua
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800164
Subject(s) - chemistry , sulfur , sodium , metal , iodine , organic chemistry , inorganic chemistry
An iodine‐PPh 3 mediated sulfenylation of indoles in water with stable and odorless sodium sulfinates as the sulfur source is described. The reaction could afford monosulfenylated indoles in moderate to excellent yields under metal free conditions. Moreover, double C—H sulfenylation of indoles at 2‐ and 3‐positions has also been achieved by using excess sodium sulfinates under the optimized reaction conditions.