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Palladium‐Catalyzed Intermolecular Oxidative Coupling Reactions of ( Z )‐Enamines with Isocyanides through Selective β‐C(sp 2 )‐H and/or C=C Bond Cleavage
Author(s) -
Hu Weigao,
Zheng Jia,
Li Meng,
Wu Wanqing,
Liu Haiyang,
Jiang Huanfeng
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201800127
Subject(s) - chemistry , intramolecular force , palladium , intermolecular force , bond cleavage , catalysis , oxidative addition , cleavage (geology) , hydrogen bond , coupling reaction , stereochemistry , medicinal chemistry , organic chemistry , molecule , geotechnical engineering , fracture (geology) , engineering
Herein, two efficient palladium‐catalyzed intermolecular oxidative coupling reactions of ( Z )‐enamines with isocyanides via selective β‐C(sp 2 )‐H and/or C=C bond cleavage have been developed, leading to controllable chemodivergent and stereoselective construction of a wide range of ( E )‐β‐carbamoylenamine derivatives containing strong intramolecular hydrogen bonds. Furthermore, possible reaction pathways for these transformations are proposed on the basis of preliminary mechanism studies.