Asymmetric α‐Alkylation of β‐Ketocarbonyls via Direct Phenacyl Bromide Photolysis by Chiral Primary Amine | Zendy

Zhang Wenzhao | Zendy; Zhu Yunbo | Zendy; Zhang Long | Zendy; Luo Sanzhong | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Asymmetric α‐Alkylation of β‐Ketocarbonyls via Direct Phenacyl Bromide Photolysis by Chiral Primary Amine

Author(s) -

Zhang Wenzhao,

Zhu Yunbo,

Zhang Long,

Luo Sanzhong

Publication year - 2018

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201800125

Subject(s) - chemistry , phenacyl , stereocenter , alkylation , amine gas treating , enantioselective synthesis , primary (astronomy) , photochemistry , phenacyl bromide , photosensitizer , bromide , halide , catalysis , combinatorial chemistry , organic chemistry , physics , astronomy

Enantioselective α‐photoalkylation of β‐ketocarbonyls without any external photosensitizer was described in this work. The photoalkylation reactions, enabled solely by a chiral primary amine catalyst, provided convenient constructions of all‐carbon quaternary stereocenters with good activity and high enantioselectivity. Mechanism studies revealed a direct photolytic radical chain process under visible light irradiation.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research