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Visible Light Promoted β‐C—H Alkylation of β‐Ketocarbonyls via a β‐Enaminyl Radical Intermediate
Author(s) -
Wang Dehong,
Zhang Long,
Luo Sanzhong
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700785
Subject(s) - chemistry , enamine , alkylation , photochemistry , electron transfer , visible spectrum , organic chemistry , catalysis , physics , optoelectronics
A 5πe carbonyl activation mode is reported on the basis of photo‐induced single‐electron‐transfer (SET) oxidation of a secondary enamine. The resultant β‐enaminyl radical intermediate was trapped by a wide range of Michael acceptors, producing β‐alkylation products of β‐ketocarbonyls in a highly efficient manner.