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Methylation of Arenols through Ni‐catalyzed C—O Activation with Methyl Magnesium Bromide
Author(s) -
Shi WenJuan,
Shi ZhangJie
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700664
Subject(s) - chemistry , reagent , magnesium bromide , alkylation , methylation , magnesium , catalysis , bromide , substrate (aquarium) , alcohol , alkyl , benzyl bromide , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , gene , oceanography , geology
Direct alkylation of arenols with alkyl organometallic reagents has never been approached. Herein we reported the first successful example of nickel‐catalyzed methylation of arenols with methyl Grignard reagents to construct C(sp 2 )‐C(sp 3 ) bond under mild conditions. The transformation was compatible with broad substrate scope of 2‐naphthol derivatives. Benzyl alcohol and biphenols were also suitable substrates for this methylation.