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Cipaferoids A–C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera
Author(s) -
Yu Jinhai,
Zhou Bin,
Dalal Seema,
Liu Qunfang,
Cassera Maria B.,
Yue Jianmin
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700627
Subject(s) - chemistry , chirality (physics) , stereochemistry , physics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
Three limonoids cipaferoids A–C ( 1 – 3 ) representing two different scaffolds were isolated from Cipadessa baccifera . Their structures were completely assigned by spectroscopic data, CD exciton chirality method, and X‐ray crystallography. Compounds 2 and 3 exhibited moderate antimalarial activity with IC 50 values of 9.3±0.1 and 14.7±4.8 μmol•L –1 , respectively.