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Nickel‐Catalyzed Difluoromethylation of Arylboronic Acids with Bromodifluoromethane
Author(s) -
Fu XiaPing,
Xiao YuLan,
Zhang Xingang
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700624
Subject(s) - chemistry , catalysis , nickel , scope (computer science) , fluorine , combinatorial chemistry , substrate (aquarium) , functional group , reaction conditions , organic chemistry , oceanography , computer science , programming language , geology , polymer
Although bromodifluoromethane (BrCF 2 H) is a simple and readily available fluorine source, direct formation of difluoromethylated arenes with BrCF 2 H has not been reported. Herein, we describe an efficient method to access difluoromethylated arenes through a nickel‐catalyzed difluoromethylation of arylboronic acids with BrCF 2 H. The reaction exhibits high efficiency, good functional group tolerance and broad substrate scope, thus providing an efficient route for applications in drug discovery and development. Preliminary mechanistic studies reveal that a difluoromethyl radical is involved in the reaction.