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Iron‐Catalyzed Aerobic Oxidation of Aldehydes: Single Component Catalyst and Mechanistic Studies
Author(s) -
Jiang Xingguo,
Zhai Yizhan,
Chen Junyu,
Han Yulin,
Yang Zheng,
Ma Shengming
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700576
Subject(s) - chemistry , catalysis , oxygen , molecular oxygen , component (thermodynamics) , organic chemistry , physics , thermodynamics
An aerobic oxidation of aldehydes towards carboxylic acids in MeCN using 1 atm of pure oxygen or oxygen in air as the oxidant and a catalytic amount of single component catalyst, Fe(NO 3 ) 3 · 9H 2 O, has been developed. Carboxylic acids with different synthetically useful functional groups were obtained at room temperature. Two mechanistic pathways have been proposed based on isotopic labeling, NMR monitoring, and control experiments. The practicality of this reaction has been demonstrated by conducting several 50 mmol‐scale reactions using pure oxygen or an air‐flow of ~30 mL/min.