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Gold(I)‐Catalyzed Diastereo‐ and Enantioselective Synthesis of Polysubstituted Pyrrolo[3,4‐ d ][1,2]oxazines
Author(s) -
Zhang Mei,
Di Xiaoyu,
Zhang Mingrui,
Zhang Junliang
Publication year - 2018
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700575
Subject(s) - chemistry , enantioselective synthesis , cycloaddition , oxazines , catalysis , combinatorial chemistry , substrate (aquarium) , ligand (biochemistry) , oxime , intermolecular force , organic chemistry , molecule , oceanography , receptor , geology , biochemistry
A gold(I)‐catalyzed highly diastereo‐ and enantioselective intermolecular cycloaddition of oxime ethers with nitrones under mild conditions was developed, which provides an facile access to optically pure highly substituted pyrrolo[3,4‐ d ][1,2]oxazines. The salient features of this reaction include general substrate scope, high efficiency, high enantioselectivity, readily available starting materials, and the use of commercially available ligand.