Two New  C 19  ‐Diterpenoid Alkaloids with Anti‐inflammatory Activity from  Aconitum iochanicum | Zendy

Guo Ruihua | Zendy; Guo Chengxin | Zendy; He Dan | Zendy; Zhao Dake | Zendy; Shen Yong | Zendy

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Two New C 19 ‐Diterpenoid Alkaloids with Anti‐inflammatory Activity from Aconitum iochanicum

Author(s) -

Guo Ruihua,

Guo Chengxin,

He Dan,

Zhao Dake,

Shen Yong

Publication year - 2017

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201700401

Subject(s) - chemistry , terpenoid , aconitum , alkaloid , ranunculaceae , nitric oxide , stereochemistry , organic chemistry , botany , biology

Two new C 19 ‐diterpenoid alkaloids, 7,8‐epoxy‐franchetine ( 1 ) and N(19)‐en‐austroconitine A ( 2 ), were isolated from Aconitum iochanicum . Compound 1 was a new C 19 ‐diterpenoid alkaloid with a 7,8‐epoxy unit. Their structures were elucidated by comprehensive spectroscopic analyses including UV , IR , MS , 1D and 2D NMR . Biological activity tests indicated that two new compounds exhibited inhibitory activity against nitric oxide ( NO ) production in LPS ‐activated RAW264 .7 macrophages. Compared with positive control, the two new compounds showed weak anti‐inflammatory effects with the inhibition rate of 27.3% and 29.2%, respectively.

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