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Three New Chromone Derivatives Produced by Phomopsis sp. HNY29‐2B from Acanthus ilicifolius Linn.
Author(s) -
Ding Bo,
Wang Zhiyuan,
Xia Guoping,
Huang Xishan,
Xu Fang,
Chen Wenrui,
She Zhigang
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700375
Subject(s) - chemistry , chromone , du145 , circular dichroism , stereochemistry , cytotoxicity , proton nmr , carbon 13 nmr , cancer cell , biochemistry , cancer , medicine , lncap , in vitro
Three new chromone derivatives, phomochromenones A‐C ( 1–3 ), and one known chaetocyclinone B ( 4 ) were obtained from the cultures of Phomopsis sp. HNY29‐2B isolated from the mangrove Acanthus ilicifolius Linn., which was collected from the South China Sea. Their structures were determined by the analysis of 1 D NMR and 2 D NMR as well as mass spectroscopic data. The absolute configurations of 1 and 2 were assigned by quantum chemical calculations of the electronic circular dichroism ( ECD ) spectra. Compound 3 is the third example of alkaloids possessing the unique chromeno [3,2‐ c ] pyridine nucleus. In the bioactivity assay, compound 4 showed cytotoxicity against human prostate cancer cell lines ( PC ‐3 and DU145 cells) with the IC 50 values of 8.13 and 3.59 µmol/L, respectively.