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Regioselective Synthesis of SCF 3 ‐Substituted 2,4‐Diarylquinazoline Using AgSCF 3 as Trifluoromethylthiolation Reagent
Author(s) -
Gao Wei,
Ding Qiuping,
Yuan Jianjun,
Mao Xuechun,
Peng Yiyuan
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700289
Subject(s) - chemistry , regioselectivity , reagent , aryl , halogenation , combinatorial chemistry , tandem , functional group , substrate (aquarium) , reaction conditions , catalysis , organic chemistry , medicinal chemistry , polymer , composite material , geology , alkyl , materials science , oceanography
A facile and efficient route to 4‐aryl‐2‐[2‐(trifluoromethylthio) aryl]quinazoline derivatives through a tandem directed Rh‐catalyzed C‐H iodination and trifluoromethylthiolation is described. This strategy provides an access to various structurally versatile trifluoromethylthiolated 2,4‐diarylquinazolines with potentially useful biological and pharmaceutical activities.