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Oxidative Rearrangement of Isatins with Arylamines Using H 2 O 2 as Oxidant: A Facile Synthesis of Quinazoline‐2,4‐diones and Evaluation of Their Antibacterial Activity
Author(s) -
Shi Guanghao,
He Xinwei,
Shang Yongjia,
Yang Cheng,
Xiang Liwei
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700280
Subject(s) - chemistry , hydrogen peroxide , staphylococcus epidermidis , klebsiella pneumonia , staphylococcus aureus , antibacterial activity , broth microdilution , antimicrobial , quinazoline , oxidative phosphorylation , escherichia coli , gram positive bacteria , microbiology and biotechnology , bacteria , combinatorial chemistry , minimum inhibitory concentration , organic chemistry , biochemistry , gene , genetics , biology
A green and highly efficient synthetic method for the synthesis of quinazoline‐2,4‐diones with hydrogen peroxide as the terminal oxidant has been developed. The reaction features the mild reaction conditions, broad substrate scope, metal‐free catalysts, and sole byproduct water. A plausible mechanism for this process was proposed. Moreover, an antibacterial activity study was performed to evaluate the antimicrobial activities towards two Gram‐negative bacterial strains ( Escherichia coli , and Klebsiella pneumonia ) and two Gram‐positive bacterial strains ( Staphylococcus epidermidis , and Staphylococcus aureus ) using the Broth microdilution method.