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Asymmetric Synthesis of Chiral Trifluoromethyl Containing Heterocyclic Amino Acids
Author(s) -
Zhao Liang,
Zhou Shengbin,
Tong Junhua,
Wang Jiang,
Liu Hong
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700257
Subject(s) - chemistry , trifluoromethyl , amino acid , glycine , enantioselective synthesis , organic chemistry , combinatorial chemistry , stereochemistry , catalysis , biochemistry , alkyl
An operationally convenient, asymmetric synthesis of chiral trifluoromethyl containing heterocyclic amino acids has been developed via Michael addition reaction of chiral equivalent of Ni(II)‐complex of glycine and β ‐trifluoromethylated‐ α , β ‐unsaturated ketones. The simplicity of the experimental procedures and high stereochemical outcome of the presented method render these heterocyclic amino acids readily available for systematic medicinal chemistry studies and de novo peptide design.