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Synthesis of 2‐Amino‐1,3,4‐oxadiazoles through Elemental Sulfur Promoted Cyclization of Hydrazides with Isocyanides
Author(s) -
Bao Wenhu,
Chen Chuang,
Yi Niannian,
Jiang Jun,
Zeng Zebing,
Deng Wei,
Peng Zhihong,
Xiang Jiannan
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700188
Subject(s) - chemistry , sulfur , scope (computer science) , combinatorial chemistry , oxadiazole , organic chemistry , amino acid , programming language , biochemistry , computer science
A novel sulfur‐promoted cyclization of hydrazides and isonitriles to produce 1,3,4‐oxadiazole has been developed. The method is operationally simple and compatible with a wide scope of substrates and various 2‐amino‐ 1,3,4‐oxadiazoles are efficiently obtained in good yields.
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