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A Facile Synthesis of Benzo[ h ]quinolines via Silica‐ TsOH‐P 2 O 5 Promoted Condensation of 1‐Naphthylamines with 1,3‐Diketones under Solvent Free Conditions
Author(s) -
Zhu Chuanlei,
Guo Ruiqiang,
Sheng Zhe,
Li Yanzhe,
Chu Changhu
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700128
Subject(s) - chemistry , phosphorus pentoxide , catalysis , condensation , condensation reaction , p toluenesulfonic acid , phosphorus , pentoxide , silica gel , solid acid , solvent , organic chemistry , nuclear chemistry , vanadium , physics , thermodynamics
A facile synthesis of benzo[ h ]quinolines has been developed via improved Combes reaction. A combination of silica gel, p ‐toluenesulfonic acid and phosphorus pentoxide was utilized to promote the condensation of 1‐naphthylamines with 1,3‐diketones under solvent free conditions. In this case, silica gel was used as reaction media, p ‐toluenesulfonic acid and phosphorus pentoxide were acted as catalyst and dehydrating agent, respectively.