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Photodynamic Therapy of Oligoethylene Glycol‐Dendronized Reduction‐Sensitive Porphyrins
Author(s) -
Ju Mingjie,
Pang Jundi,
Xu Ligong
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700070
Subject(s) - chemistry , photodynamic therapy , reduction (mathematics) , combinatorial chemistry , nanotechnology , organic chemistry , materials science , geometry , mathematics
Graphene oxide ( GO ) and its functionalized derivatives have attracted increasing attention in medical treatment. Herein, a reduction sensitive PEI‐GO ‐ SS ‐ TPP was synthesized for photodynamic therapy. More than 80% porphyrin release was observed in the presence of 10 mmol•L −1 DTT in one day. The confocal laser scanning microscopy confirmed that the cell uptake efficiency of PEI‐GO‐SS‐TPP was remarkably enhanced as compared to free porphyrin which was significantly dependent on incubation time. For photodynamic therapy, GSH‐OEt could effectively increase the photodynamic therapy efficiency of PEI‐GO ‐ SS ‐ TPP . Compared with free porphyrin, the toxicity from PEI‐GO ‐ SS ‐ TPP is much higher with a low IC 50 (2.1 µg/ mL ) value. All results indicate that the PEI‐GO ‐ SS ‐ TPP PSs are promising for photodynamic therapy.