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Asymmetric Synthesis and Antitumor Activity of Spiro‐Oxadiazole Derivatives from 1,4:3,6‐Dianhydro‐ D ‐fructose
Author(s) -
Xu Wenke,
Ge Yongxun,
Hou Yu,
Liu Yingju,
Hua Yingchun,
Han Weiwei,
Qin Zhiyan,
Liu Fengwu
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700058
Subject(s) - chemistry , stereochemistry , in vitro , fructose , combinatorial chemistry , organic chemistry , biochemistry
A series of spiro‐oxadiazoles were synthesized from 1,4:3,6‐dianhydro‐ D ‐fructose and hydrazides via a stereo‐ selective two‐step reaction sequence. The structures of newly synthesized compounds were established by spectral analysis. The absolute configuration of compound 2a was further confirmed by single crystal X‐ray analysis. All the synthesized compounds were screened for their in vitro antitumor activity, showing that these compounds have poor inhibitory activities against A549, MGC‐803 tumor cells.