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Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3‐Triazole Linked Quinazoline Derivatives
Author(s) -
Song Panpan,
Cui Fei,
Li Na,
Xin Jingchao,
Ma Qisheng,
Meng Xiangchuan,
Wang Chaojie,
Cao Qinpo,
Gu Yifei,
Ke Yu,
Zhang Qiurong,
Liu Hongmin
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201700005
Subject(s) - chemistry , quinazoline , cytotoxic t cell , mtt assay , in vitro , cancer cell lines , triazole , combinatorial chemistry , stereochemistry , cell culture , cytotoxicity , cancer cell , cancer , biochemistry , organic chemistry , medicine , biology , genetics
A series of novel 1,2,3‐triazole‐quinazoline derivatives were synthesized in five steps starting from anthranilamide by conventional methods. All the title compounds 10a — 10r were evaluated for cytotoxic activity against four human cancer cell lines ( MGC ‐803, EC ‐109, MCF ‐7 and HGC ‐27) using MTT assay in vitro . Some of the synthesized compounds exhibited moderate to potent activity against tested cancer cell lines. Among them, compounds 10 h and 10q exhibited excellent growth inhibition against HGC ‐27 and compound 10 m also possessed excellent activity against MCF ‐7, with IC 50 values less than 1 µmol/L. Especially, compound 10 h was more cytotoxic than 5‐fluorouracil against all tested four human cancer cell lines.