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Synthesis of 1,2,4‐Triazine Compounds via Two Distinct One‐Pot Domino Protocols
Author(s) -
Liu Yafeng,
Guo Xin,
Tang Dong,
Wang Jing,
Wu Ping,
Han Jianwei,
Chen Baohua
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600922
Subject(s) - chemistry , domino , triazine , environmentally friendly , combinatorial chemistry , functional group , transition metal , reaction conditions , organic chemistry , catalysis , ecology , polymer , biology
1,2,4‐Triazine compounds were synthesized via two coupled domino strategies employing simple and readily available arylacetaldehydes/arylethyl alcohols as starting materials. The reactions proceed smoothly in one pot with the advantages of high functional groups tolerance, being transition metal‐free, and employing environmentally friendly oxidants such as I 2 and IBX , providing access to the desired 1,2,4‐triazine products in excellent yields.