Synthesis of 1,2,4‐Triazine Compounds via Two Distinct One‐Pot Domino Protocols | Zendy

Liu Yafeng | Zendy; Guo Xin | Zendy; Tang Dong | Zendy; Wang Jing | Zendy; Wu Ping | Zendy; Han Jianwei | Zendy; Chen Baohua | Zendy

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Synthesis of 1,2,4‐Triazine Compounds via Two Distinct One‐Pot Domino Protocols

Author(s) -

Liu Yafeng,

Guo Xin,

Tang Dong,

Wang Jing,

Wu Ping,

Han Jianwei,

Chen Baohua

Publication year - 2017

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201600922

Subject(s) - chemistry , domino , triazine , environmentally friendly , combinatorial chemistry , functional group , transition metal , reaction conditions , organic chemistry , catalysis , ecology , polymer , biology

1,2,4‐Triazine compounds were synthesized via two coupled domino strategies employing simple and readily available arylacetaldehydes/arylethyl alcohols as starting materials. The reactions proceed smoothly in one pot with the advantages of high functional groups tolerance, being transition metal‐free, and employing environmentally friendly oxidants such as I 2 and IBX , providing access to the desired 1,2,4‐triazine products in excellent yields.

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