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Pd(0)‐Catalyzed Tandem One‐Pot Reaction of Biphenyl Ketones/Aldehydes to the Corresponding Di‐substituted Aryl Olefins
Author(s) -
Liu Yang,
Liu Ping,
Liu Yan,
Wei Yu
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600870
Subject(s) - chemistry , aryl , biphenyl , halide , catalysis , coupling reaction , tandem , organic chemistry , lithium (medication) , medicinal chemistry , aryl halide , alkyl , medicine , materials science , composite material , endocrinology
Synthesis of di‐substituted aryl olefins via a Pd(0)‐catalyzed cross‐coupling reaction of biphenyl ketones/aldehydes, tosylhydrazide, and aryl bromides (or benzyl halides) was developed. This methodology was achieved by one‐pot two‐step reactions involving the preparation of N ‐tosylhydrazones by reacting tosylhydrazide with biphenyl ketones/aldehydes, followed by coupling with aryl bromides (or benzyl halides) in the presence of Pd( PPh 3 ) 4 and lithium t ‐butoxide to produce various di‐substituted aryl olefins in moderate to good yields.
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