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Conjugate Hydrocyanation of Chalcone Derivatives Using Ethyl Cyanoacetate as an Organic Cyanide Source
Author(s) -
Li Zheng,
Yin Junjun
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600860
Subject(s) - hydrocyanation , chemistry , chalcone , ethyl cyanoacetate , reagent , conjugate , cyanide , yield (engineering) , organic chemistry , combinatorial chemistry , malononitrile , catalysis , mathematical analysis , materials science , mathematics , metallurgy
The conjugate hydrocyanation of chalcone derivatives using ethyl cyanoacetate as an organic cyanide source at room temperature under open air and transition metal‐free conditions was described. The protocol has advantages of using relatively cheap, less toxic, stable and easy‐to‐handle cyanating reagent, high yield, and mild reaction condition.