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Direct Triflylation of Benzylic C—H Bonds with Pyridine as a Directing Group
Author(s) -
Yang Jun,
Hu Juanjuan,
Huang Yangen,
Xu Xiuhua,
Qing Fengling
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600826
Subject(s) - chemistry , pyridine , group (periodic table) , medicinal chemistry , stereochemistry , organic chemistry
The first example of benzylic C—H triflylation was accomplished with pyridine as a directing group. The reaction of various 2‐benzylpyridines and ( CF 3 SO 2 ) 2 O in the presence of NEt 3 in CH 2 Cl 2 proceeded smoothly to afford the corresponding benzyl triflones in moderate to high yields.