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Facile Preparation of Water‐Soluble and Cytocompatible Small‐Sized Chitosan‐Polydopamine Nanoparticles
Author(s) -
Ni Yunzhou,
Chen Feng,
Shi Leilei,
Tong Gangsheng,
Wang Jie,
Li Huimei,
Yu Chunyang,
Zhou Yongfeng
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600765
Subject(s) - chemistry , chitosan , nanoparticle , polymerization , yield (engineering) , chemical engineering , molar ratio , nuclear chemistry , fraction (chemistry) , polymer chemistry , nanotechnology , polymer , chromatography , organic chemistry , catalysis , materials science , engineering , metallurgy
In this paper, a kind of novel water‐soluble chitosan‐polydopamine ( CHT‐PDA ) nanoparticles with a hydrodynamic diameter ( D h ) around 10 nm were reported by the combination of self‐polymerization of PDA and electrostatic complexation between PDA and CHT in water/ DMSO (W/D) mixture at the molar fraction of DMSO ( x DMSO = 0.37). The preparation method was efficient with a yield of 98% around. The as‐prepared water‐soluble CHT‐PDA nanoparticles exhibited effective UV ‐screen ability, enhanced visible‐light transmittance and good cytocompatibility via MTT assay, which might be used in transparent formulation for UV protection usage, especially in biological field including sun care application.