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Silver‐Catalyzed Cascade Radical Cyclization for Stereoselective Synthesis of Exocyclic Phosphine Oxides
Author(s) -
Mao Liuliang,
Li Yonghong,
Yang Shangdong
Publication year - 2017
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201600707
Subject(s) - chemistry , stereoselectivity , phosphine , radical cyclization , catalysis , cascade , substrate (aquarium) , combinatorial chemistry , cascade reaction , double bond , medicinal chemistry , organic chemistry , oceanography , chromatography , geology
Abstract A silver‐catalyzed phosphorylation/cyclization radical cascade of 1,6‐dienes has been developed. The reaction process involves in a one‐pot operation described as an autotandem catalytic process with a cascading radical cyclization for the construction of C—P and C—C bond with high stereoselectivity. Moreover, it also affords an efficient method for the synthesis of valuable exocyclic phosphine oxides compounds with broad substrate applicability, mild reaction condition and succinct reaction system.